HMBS purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Western Blot (Transfected lysate)
Western Blot analysis of HMBS expression in transfected 293T cell line (H00003145-T01) by HMBS MaxPab polyclonal antibody.
Lane 1: HMBS transfected lysate(39.30 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to HMBS on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human HMBS protein.
Immunogen
HMBS (NP_000181.2, 1 a.a. ~ 361 a.a) full-length human protein.
Sequence
MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLNDAH
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (91); Rat (91)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of HMBS expression in transfected 293T cell line (H00003145-T01) by HMBS MaxPab polyclonal antibody.
Lane 1: HMBS transfected lysate(39.30 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to HMBS on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — HMBS
Entrez GeneID
3145GeneBank Accession#
NM_000190.3Protein Accession#
NP_000181.2Gene Name
HMBS
Gene Alias
PBG-D, PBGD, UPS
Gene Description
hydroxymethylbilane synthase
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
porphobilinogen deaminase|pre-uroporphyrinogen synthase|uroporphyrinogen I synthase|uroporphyrinogen I synthetase
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Interactome
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Pathway
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Disease
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Publication Reference
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Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy.
Anand S, Wilson C, Hasan T, Maytin EV.
Cancer Research 2011 Sep; 71(18):6040.
Application：WB-Ti, Human, A-431 tumor lysates.
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Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy.
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