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Last updated: 2017/2/26
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HLA-DRB5 (Human) IP-WB Antibody Pair

  • Catalog # : H00003127-PW1
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  • Specification
  • Product Description:
  • This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Immunoprecipitation-Western Blot (IP-WB)

    QC Testing of H00003127-PW1
    Immunoprecipitation of HLA-DRB5 transfected lysate using rabbit polyclonal anti-HLA-DRB5 and Protein A Magnetic Bead (U0007), and immunoblotted with mouse polyclonal anti-HLA-DRB5.
  • Supplied Product:
  • Antibody pair set content:
    1. Antibody pair for IP: rabbit polyclonal anti-HLA-DRB5 (300 ul)
    2. Antibody pair for WB: mouse polyclonal anti-HLA-DRB5 (50 ul)
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Applications
  • Application Image
  • Immunoprecipitation-Western Blot
  • Gene Information
  • Entrez GeneID:
  • 3127
  • Gene Name:
  • HLA-DRB5
  • Gene Alias:
  • -
  • Gene Description:
  • major histocompatibility complex, class II, DR beta 5
  • Gene Summary:
  • HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq
  • Other Designations:
  • HLA class II histocompatibility antigen, DR-5 beta chain,MHC HLA-DR-beta cell surface glycoprotein,MHC HLA-DR-beta chain,MHC class II HLA beta chain,MHC class II antigen,OTTHUMP00000029035,human leucocyte antigen DRB5,leukocyte antigen class II
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