HLA-DRB3 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-HLA-DRB3 full-length
Host
Human
Theoretical MW (kDa)
30
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-HLA-DRB3 antibody (H00003125-B02) by Western Blots.
SDS-PAGE Gel
HLA-DRB3 transfected lysate
Western Blot
Lane 1: HLA-DRB3 transfected lysate ( 30 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — HLA-DRB3
Entrez GeneID
3125GeneBank Accession#
NM_022555Protein Accession#
NP_072049Gene Name
HLA-DRB3
Gene Alias
HLA-DR3B, MGC117330
Gene Description
major histocompatibility complex, class II, DR beta 3
Gene Ontology
HyperlinkGene Summary
HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq
Other Designations
MHC class II HLA-DR beta 3 chain|MHC class II antigen DR beta 3 chain|human leucocyte antigen DRB3
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Interactome
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Disease
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