HLA-DOB 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-HLA-DOB full-length
Host
Human
Theoretical MW (kDa)
30.8
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-HLA-DOB antibody (H00003112-B01) by Western Blots.
SDS-PAGE Gel
HLA-DOB transfected lysate
Western Blot
Lane 1: HLA-DOB transfected lysate ( 30.8 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — HLA-DOB
Entrez GeneID
3112GeneBank Accession#
NM_002120Protein Accession#
NP_002111Gene Name
HLA-DOB
Gene Alias
DOB
Gene Description
major histocompatibility complex, class II, DO beta
Omim ID
600629Gene Ontology
HyperlinkGene Summary
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq
Other Designations
HLA class II histocompatibility antigen, DO beta chain|OTTHUMP00000029312|class II beta chain
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