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HLA-C rabbit monoclonal antibody

  • Catalog # : H00003107-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human HLA-C peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human HLA-C is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human HLA-C peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • Application Image
  • Western Blot (Transfected lysate)
  • Gene Information
  • Entrez GeneID:
  • 3107
  • GeneBank Accession#:
  • HLA-C
  • Gene Name:
  • HLA-C
  • Gene Alias:
  • D6S204,FLJ27082,HLA-Cw,HLA-Cw12,HLA-JY3,HLC-C,PSORS1
  • Gene Description:
  • major histocompatibility complex, class I, C
  • Gene Summary:
  • HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq
  • Other Designations:
  • HLA class I antigen,HLA class I heavy chain,HLA class I histocompatibility antigen, C alpha chain,HLA-C (Cw*1201),HLA-Cw*050x,MHC class I HLA-C,MHC class I HLA-Cw*0803,MHC class I antigen HLA-C,MHC class I antigen heavy chain HLA-C,MHC class I protein HLA
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