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Last updated: 2016/12/4

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UBE2K rabbit monoclonal antibody

  • Catalog # : H00003093-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human UBE2K peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human UBE2K is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human UBE2K peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 3093
  • GeneBank Accession#:
  • UBE2K
  • Gene Name:
  • UBE2K
  • Gene Alias:
  • DKFZp564C1216,DKFZp686J24237,E2-25K,HIP2,HYPG,LIG
  • Gene Description:
  • ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
  • Gene Summary:
  • The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
  • Other Designations:
  • huntingtin interacting protein 2,ubiquitin carrier protein,ubiquitin-conjugating enzyme E2-25 KDA,ubiquitin-conjugating enzyme E2-25K,ubiquitin-protein ligase
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