Products

Western Blot (Tissue lysate)

HGF MaxPab rabbit polyclonal antibody. Western Blot analysis of HGF expression in mouse testis.

Western Blot (Cell lysate)

HGF MaxPab rabbit polyclonal antibody. Western Blot analysis of HGF expression in Raw 264.7.

Western Blot (Transfected lysate)

Western Blot analysis of HGF expression in transfected 293T cell line (H00003082-T02) by HGF MaxPab polyclonal antibody.

Lane 1: HGF transfected lysate(83.10 KDa).
Lane 2: Non-transfected lysate.

In situ Proximity Ligation Assay (Cell)

Proximity Ligation Analysis of protein-protein interactions between HGF and FN1. HeLa cells were stained with anti-HGF rabbit purified polyclonal 1:1200 and anti-FN1 mouse purified polyclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

In situ Proximity Ligation Assay (Cell)

Proximity Ligation Analysis of protein-protein interactions between HGF and MET. Mahlavu cells were stained with anti-HGF rabbit purified polyclonal 1:1200 and anti-MET mouse purified polyclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

Entrez GeneID

3082

GeneBank Accession#

NM_000601

Protein Accession#

NP_000592.3

Gene Name

HGF

Gene Alias

F-TCF, HGFB, HPTA, SF

Gene Description

hepatocyte growth factor (hepapoietin A; scatter factor)

Omim ID

142409

Gene Ontology

Hyperlink

Gene Summary

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq

Other Designations

fibroblast-derived tumor cytotoxic factor|hepatocyte growth factor|hepatopoietin A|lung fibroblast-derived mitogen|scatter factor