CFHR1 monoclonal antibody (M01), clone 4D7
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant CFHR1.
Immunogen
CFHR1 (AAH16755.1, 19 a.a. ~ 330 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CFHR1 is approximately 1ng/ml as a capture antibody.ELISA
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Gene Info — CFHR1
Entrez GeneID
3078GeneBank Accession#
BC016755Protein Accession#
AAH16755.1Gene Name
CFHR1
Gene Alias
CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2, MGC104329
Gene Description
complement factor H-related 1
Omim ID
134371Gene Ontology
HyperlinkOther Designations
H factor (complement)-like 1|H factor (complement)-like 2|OTTHUMP00000034408|complement factor H-related 1 pseudogene
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Interactome
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Disease
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Publication Reference
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins.
Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Antje J Baeumner, Mark-Steven Steiner, Mihály Józsi, Erik J M Toonen, Diana Pauly, SciFiMed consortium.
Frontiers in Immunology 2021 Mar; 12:660194.
Application:IHC, Human, Human kidney.
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Glomerular complement factor H related protein 5 (FHR5) is highly prevalent in C3 glomerulopathy and associated with renal impairment.
Medjeral-Thomas NR, Moffitt H, Lomax-Browne HJ, Constantinou N, Cairns T, Cook HT, Pickering MC.
Kidney International Reports 2019 Jun; 4(10):1387.
Application:IF, IHC-P, Human, Human kidney.
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Electrochemical ELISA-based platform for bladder cancer protein biomarker detection in urine.
Arya SK, Estrela P.
Biosensors & Bioelectronics 2018 Oct; 117:620.
Application:ELISA, Func, N/A, Synthetic urine.
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Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin-Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H-Related Protein-5 (FHR5) Deposition.
Medjeral-Thomas NR, Troldborg A, Constantinou N, Lomax-Browne HJ, Hansen AG, Willicombe M, Pusey CD, Cook HT, Thiel S, Pickering MC.
Kidney International Reports 2017 Nov; 3(2):426.
Application:IHC-P, Human, Human kidneys.
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins.
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