HEXB 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
HEXB transfected lysate.
Western Blot
Lane 1: HEXB transfected lysate ( 63.1 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-HEXB full-length
Host
Human
Theoretical MW (kDa)
63.1
Interspecies Antigen Sequence
Mouse (78); Rat (74)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-HEXB antibody (H00003074-B01) by Western Blots.
SDS-PAGE Gel
HEXB transfected lysate.
Western Blot
Lane 1: HEXB transfected lysate ( 63.1 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — HEXB
Entrez GeneID
3074GeneBank Accession#
NM_000521.2Protein Accession#
-Gene Name
HEXB
Gene Alias
ENC-1AS
Gene Description
hexosaminidase B (beta polypeptide)
Gene Ontology
HyperlinkGene Summary
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). [provided by RefSeq
Other Designations
N-acetyl-beta-glucosaminidase|OTTHUMP00000128232|hexosaminidase B
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Interactome
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Pathway
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Disease
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