HBG1 polyclonal antibody (A02)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant HBG1.
Immunogen
HBG1 (NP_000550, 44 a.a. ~ 106 a.a) partial recombinant protein with GST tag.
Sequence
DSFGNLSSASAIMGNPKVKAHGKKVLTSLGDATKHLDDLKGTFAQLSELHCDKLHVDPENFKL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (78)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (33.04 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — HBG1
Entrez GeneID
3047GeneBank Accession#
NM_000559Protein Accession#
NP_000550Gene Name
HBG1
Gene Alias
HBGA, HBGR, HSGGL1, PRO2979
Gene Description
hemoglobin, gamma A
Omim ID
142200Gene Ontology
HyperlinkGene Summary
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq
Other Designations
A-gamma globin|gamma A hemoglobin|gamma globin|hemoglobin gamma-a chain|hemoglobin, gamma, regulator of
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Interactome
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Disease
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Publication Reference
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Response Predictors to Calcineurin Inhibitors in Patients with Primary Membranous Nephropathy.
Yu X, Cai J, Jiao X, Zhang S, Liu H, Ding X.
American Journal of Nephrology 2018 Apr; 47(4):266.
Application:WB, Human, Serum.
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A Synthetic Model of Human Beta-Thalassemia Erythropoiesis Using CD34+ Cells from Healthy Adult Donors.
Lee YT, Kim KS, Byrnes C, de Vasconcellos JF, Noh SJ, Rabel A, Meier ER, Miller JL.
PLoS One 2013 Jul; 8(7):e68307.
Application:WB, Human, CD34+ cells.
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Response Predictors to Calcineurin Inhibitors in Patients with Primary Membranous Nephropathy.
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