GZMM monoclonal antibody (M03), clone 4D11
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant GZMM.
Immunogen
GZMM (NP_005308, 85 a.a. ~ 193 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
DSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (64); Rat (66)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.73 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — GZMM
Entrez GeneID
3004GeneBank Accession#
NM_005317Protein Accession#
NP_005308Gene Name
GZMM
Gene Alias
LMET1, MET1
Gene Description
granzyme M (lymphocyte met-ase 1)
Omim ID
600311Gene Ontology
HyperlinkGene Summary
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M. [provided by RefSeq
Other Designations
granzyme M|lymphocyte met-ase 1
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Interactome
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Publication Reference
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Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells.
Schiffer S, Letzian S, Jost E, Mladenov R, Hristodorov D, Huhn M, Fischer R, Barth S, Thepen T.
Cancer Letters 2013 Dec; 341(2):178.
Application:WB-Tr, Human, HEK 293T cells.
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Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells.
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