GUCA2B purified MaxPab rabbit polyclonal antibody (D01P)
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human GUCA2B protein.
Immunogen
GUCA2B (NP_009033.1, 1 a.a. ~ 112 a.a) full-length human protein.
Sequence
MGCRAASGLLPGVAVVLLLLLQSTQSVYIQYQGFRVQLESMKKLSDLEAQWAPSPRLQAQSLLPAVCHHPALPQDLQPVCASQEASSIFKTLRTIANDDCELCVNVACTGCL
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of GUCA2B expression in transfected 293T cell line (H00002981-T02) by GUCA2B MaxPab polyclonal antibody.
Lane 1: GUCA2B transfected lysate(12.10 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — GUCA2B
Entrez GeneID
2981GeneBank Accession#
NM_007102.1Protein Accession#
NP_009033.1Gene Name
GUCA2B
Gene Alias
GCAP-II, UGN
Gene Description
guanylate cyclase activator 2B (uroguanylin)
Omim ID
601271Gene Ontology
HyperlinkGene Summary
Uroguanylin and guanylin (GUCA2A; MIM 139392), peptide homologs of the bacterial heat-stable enterotoxins (e.g., the E. coli ST toxin; STa), are endogenous activators of the guanylate cyclase-2C receptor (GUCY2C; MIM 601330), which synthesizes cyclic GMP (cGMP), a key component of several intracellular signal transduction pathways.[supplied by OMIM
Other Designations
OTTHUMP00000007927|uroguanylin
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Interactome
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Disease
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Publication Reference
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Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD.
Eva M Fernández-Sáez, Maite Losarcos, Sara Becerril, Víctor Valentí, Rafael Moncada, Marina Martín, María A Burrell, Victoria Catalán, Javier Gómez-Ambrosi, Carmen Mugueta, Inmaculada Colina, Camilo Silva, Javier Escalada, Gema Frühbeck, Amaia Rodríguez.
Metabolism: Clinical and Experimental 2023 Jul; 147:1556633.
Application:IHC-P, Human, Human Liver.
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High plasma and lingual uroguanylin as potential contributors to changes in food preference after sleeve gastrectomy.
Gema Frühbeck, Sara Becerril, Marina Martín, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Victoria Catalán, Javier Gómez-Ambrosi, Camilo Silva, María A Burrell, Javier Escalada, Amaia Rodríguez.
Metabolism: Clinical and Experimental 2022 Mar; 128:155119.
Application:WB, Rat, Rat tongues.
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Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD.
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