GSTM4 monoclonal antibody (M01), clone 4B4
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant GSTM4.
Immunogen
GSTM4 (AAH15513.1, 23 a.a. ~ 119 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
YTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPD
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.41 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
GSTM4 monoclonal antibody (M01), clone 4B4. Western Blot analysis of GSTM4 expression in HeLa.Western Blot (Transfected lysate)
Western Blot analysis of GSTM4 expression in transfected 293T cell line by GSTM4 monoclonal antibody (M01), clone 4B4.
Lane 1: GSTM4 transfected lysate(25.6 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — GSTM4
Entrez GeneID
2948GeneBank Accession#
BC015513Protein Accession#
AAH15513.1Gene Name
GSTM4
Gene Alias
GSTM4-4, GTM4, MGC131945, MGC9247
Gene Description
glutathione S-transferase mu 4
Omim ID
138333Gene Ontology
HyperlinkGene Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq
Other Designations
GST class-mu 4|GTS-Mu2|OTTHUMP00000013356|OTTHUMP00000013358|S-(hydroxyalkyl)glutathione lyase M4|glutathione S-alkyltransferase M4|glutathione S-aralkyltransferase M4|glutathione S-aryltransferase M4|glutathione S-transferase M4
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Interactome
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Pathway
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Disease
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