GSTA3 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-GSTA3 full-length
Host
Human
Theoretical MW (kDa)
24.53
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-GSTA3 antibody (H00002940-B01) by Western Blots.
SDS-PAGE Gel
GSTA3 transfected lysate.
Western Blot
Lane 1: GSTA3 transfected lysate ( 24.53 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — GSTA3
Entrez GeneID
2940GeneBank Accession#
BC020619.1Protein Accession#
AAH20619.1Gene Name
GSTA3
Gene Alias
GSTA3-3, GTA3, MGC22232
Gene Description
glutathione S-transferase alpha 3
Omim ID
605449Gene Ontology
HyperlinkGene Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq
Other Designations
GST class-alpha|OTTHUMP00000016615|S-(hydroxyalkyl)glutathione lyase A3|glutathione S-alkyltransferase A3|glutathione S-aralkyltransferase A3|glutathione S-aryltransferase A3|glutathione S-transferase A3-3
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Interactome
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Pathway
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Disease
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