GRP monoclonal antibody (M03), clone 3A11
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant GRP.
Immunogen
GRP (AAH04488, 1 a.a. ~ 148 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MRGRELPLVLLALVLCLAPRGRAVPLPAGGGTVLTKMYPRGNHWAVGHLMGKKSTGESSSVSERGSLKQQLREYIRWEEAARNLLGLIEAKENRNHQPPQPKALGNQQPSWDSEDSSNFKDVGSKGKVGRLSAPGSQREGRNPQLNQQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (64); Rat (68)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (42.02 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of GRP expression in transfected 293T cell line by GRP monoclonal antibody (M03), clone 3A11.
Lane 1: GRP transfected lysate(16.39 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged GRP is 3 ng/ml as a capture antibody.ELISA
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Gene Info — GRP
Entrez GeneID
2922GeneBank Accession#
BC004488Protein Accession#
AAH04488Gene Name
GRP
Gene Alias
BN, GRP-10, preproGRP, proGRP
Gene Description
gastrin-releasing peptide
Omim ID
137260Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
bombesin|neuromedin C|pre-progastrin releasing peptide
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Interactome
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Pathway
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Disease
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