GRLF1 monoclonal antibody (M01), clone 4D4-F8
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant GRLF1.
Immunogen
GRLF1 (AAH03514, 1 a.a. ~ 36 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MEATSRSVHGDVGEVGHFEGMAVCWCPRRGILPGLR
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (35); Rat (35)
Isotype
IgG2a kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged GRLF1 is 0.1 ng/ml as a capture antibody.ELISA
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Gene Info — GRLF1
Entrez GeneID
2909GeneBank Accession#
BC003514Protein Accession#
AAH03514Gene Name
GRLF1
Gene Alias
GRF-1, KIAA1722, MGC10745, P190-A, P190A, p190RhoGAP
Gene Description
glucocorticoid receptor DNA binding factor 1
Omim ID
605277Gene Ontology
HyperlinkGene Summary
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq
Other Designations
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