GRN 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-GRN full-length
Host
Human
Theoretical MW (kDa)
65.34
Interspecies Antigen Sequence
Rat (75)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-GRN antibody (H00002896-B01) by Western Blots.
Western Blot
Lane 1: GRN transfected lysate ( 63.5 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
GRN transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — GRN
Entrez GeneID
2896GeneBank Accession#
NM_002087Protein Accession#
NP_002078Gene Name
GRN
Gene Alias
GEP, GP88, PCDGF, PEPI, PGRN
Gene Description
granulin
Gene Ontology
HyperlinkGene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq
Other Designations
PC cell-derived growth factor|acrogranin|granulin-epithelin|proepithelin|progranulin
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Interactome
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Disease
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