GRN polyclonal antibody (A01)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant GRN.
Immunogen
GRN (NP_002078, 494 a.a. ~ 593 a.a) partial recombinant protein with GST tag.
Sequence
SCEKEVVSAQPATFLARSPHVAVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (62)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.11 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
GRN polyclonal antibody (A01), Lot # 061206JCSa Western Blot analysis of GRN expression in HepG2 ( Cat # L019V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — GRN
Entrez GeneID
2896GeneBank Accession#
NM_002087Protein Accession#
NP_002078Gene Name
GRN
Gene Alias
GEP, GP88, PCDGF, PEPI, PGRN
Gene Description
granulin
Gene Ontology
HyperlinkGene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq
Other Designations
PC cell-derived growth factor|acrogranin|granulin-epithelin|proepithelin|progranulin
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Interactome
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Disease
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Publication Reference
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Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness.
Bandey I, Chiou SH, Huang AP, Tsai JC, Tu PH.
Oncogene 2015 Apr; 34(14):1853.
Application:IF, Human, Glioblastoma multiforme.
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Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness.
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