RAPGEF1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human RAPGEF1 partial ORF ( AAH41710, 1 a.a. - 110 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MGNAIEKQKPLKRSHLYPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSW
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.73
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — RAPGEF1
Entrez GeneID
2889GeneBank Accession#
BC041710Protein Accession#
AAH41710Gene Name
RAPGEF1
Gene Alias
C3G, DKFZp781P1719, GRF2
Gene Description
Rap guanine nucleotide exchange factor (GEF) 1
Omim ID
600303Gene Ontology
HyperlinkGene Summary
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000064558|guanine nucleotide-releasing factor 2|guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
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Interactome
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Pathway
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Disease
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