RAPGEF1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human RAPGEF1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human RAPGEF1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human RAPGEF1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — RAPGEF1
Entrez GeneID
2889GeneBank Accession#
RAPGEF1Gene Name
RAPGEF1
Gene Alias
C3G, DKFZp781P1719, GRF2
Gene Description
Rap guanine nucleotide exchange factor (GEF) 1
Omim ID
600303Gene Ontology
HyperlinkGene Summary
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000064558|guanine nucleotide-releasing factor 2|guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
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