GRB10 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human GRB10 peptide using ARM Technology.
Immunogen
A synthetic peptide of human GRB10 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human GRB10 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — GRB10
Entrez GeneID
2887GeneBank Accession#
GRB10Gene Name
GRB10
Gene Alias
GRB-IR, Grb-10, IRBP, KIAA0207, MEG1, RSS
Gene Description
growth factor receptor-bound protein 10
Omim ID
601523Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
GRB10 adaptor protein|insulin receptor-binding protein Grb-IR|maternally expressed gene 1
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Interactome
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Disease
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