GLE1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human GLE1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human GLE1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human GLE1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — GLE1
Entrez GeneID
2733GeneBank Accession#
GLE1Gene Name
GLE1
Gene Alias
GLE1L, LCCS, LCCS1, hGLE1
Gene Description
GLE1 RNA export mediator homolog (yeast)
Omim ID
603371Gene Ontology
HyperlinkGene Summary
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
GLE1 RNA export mediator homolog|GLE1 RNA export mediator-like|GLE1-like, RNA export mediator|OTTHUMP00000022280|OTTHUMP00000022281
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Interactome
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Disease
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