Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

GFI1

Gene Alias

FLJ94509, GFI-1, ZNF163

Gene Description

growth factor independent 1 transcription repressor

Omim ID

Gene Ontology

Gene Summary

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000012582|OTTHUMP00000012583|growth factor independence-1|growth factor independent 1|zinc finger protein 163|zinc finger protein Gfi-1