GCSH monoclonal antibody (M01), clone 3D8-A12
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant GCSH.
Immunogen
GCSH (AAH00790.1, 1 a.a. ~ 173 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MALRVVRSVRALLCTLRAVPLPAAPCPPRPWQLGVGAVRTLRTGPALLSVRKFTEKHEWVTTENGIGTVGISNFAQEALGDVVYCSLPEVGTKLNKQDEFGALESVKAASELYSPLSGEVTEINEALAENPGLVNKSCYEDGWLIKMTLSNPSELDELMSEEAYEKYIKSIEE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (80); Rat (85)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (44.77 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged GCSH is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — GCSH
Entrez GeneID
2653GeneBank Accession#
BC000790Protein Accession#
AAH00790.1Gene Name
GCSH
Gene Alias
GCE, NKH
Gene Description
glycine cleavage system protein H (aminomethyl carrier)
Gene Ontology
HyperlinkGene Summary
The enzyme system for cleavage of glycine (glycine cleavage system; EC 2.1.2.10), which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase; MIM 238300), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme; MIM 238310), and L protein (a lipoamide dehydrogenase; MIM 238331). Glycine encephalopathy (GCE; MIM 605899), also called nonketotic hyperglycinemia (NKH), may be due to a defect in any one of these enzymes.[supplied by OMIM
Other Designations
lipoic acid-containing protein|mitochondrial glycine cleavage system H-protein|part of mitochondrial matrix glycine cleavage enzyme complex of 4 proteins: H-, L-, P-, and T-proteins
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Interactome
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Disease
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