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Last updated: 2016/11/27

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GCH1 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00002643-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-GCH1 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 27.61
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-GCH1 antibody (H00002643-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00002643-T01
    GCH1 transfected lysate.
    Western Blot
    QC Testing of H00002643-T01
    Lane 1: GCH1 transfected lysate ( 27.61 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 2643
  • Gene Name:
  • GCH1
  • Gene Alias:
  • DYT14,DYT5,GCH,GTP-CH-1,GTPCH1
  • Gene Description:
  • GTP cyclohydrolase 1
  • Gene Summary:
  • This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq
  • Other Designations:
  • guanosine 5'-triphosphate cyclohydrolase I
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