GALE 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-GALE full-length
Host
Human
Theoretical MW (kDa)
38.3
Interspecies Antigen Sequence
Rat (93)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-GALE antibody (H00002582-B01) by Western Blots.
SDS-PAGE Gel
GALE transfected lysate.
Western Blot
Lane 1: GALE transfected lysate ( 38.3 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — GALE
Entrez GeneID
2582GeneBank Accession#
NM_000403.3Protein Accession#
-Gene Name
GALE
Gene Alias
FLJ95174, FLJ97302, SDR1E1
Gene Description
UDP-galactose-4-epimerase
Gene Ontology
HyperlinkGene Summary
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000002991|OTTHUMP00000044857|UDP galactose-4'-epimerase|galactose-4-epimerase, UDP-|galactowaldenase|short chain dehydrogenase/reductase family 1E, member 1
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Interactome
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Pathway
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