Immunoprecipitation of GAK transfected lysate using anti-GAK MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with GAK purified MaxPab mouse polyclonal antibody (B01P) (H00002580-B01P).
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. [provided by RefSeq