FYN monoclonal antibody (M01), clone 3G11-F9
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More Files
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Western Blot (Transfected lysate)
Western Blot analysis of FYN expression in transfected 293T cell line by FYN monoclonal antibody (M01), clone 3G11-F9.
Lane 1: FYN transfected lysate(55.43 KDa).
Lane 2: Non-transfected lysate.
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between PRKCD and FYN. HeLa cells were stained with anti-PRKCD rabbit purified polyclonal 1:1200 and anti-FYN mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
Western Blot detection against Immunogen (78.76 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant FYN.
Immunogen
FYN (AAH32496, 1 a.a. ~ 482 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (78.76 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of FYN expression in transfected 293T cell line by FYN monoclonal antibody (M01), clone 3G11-F9.
Lane 1: FYN transfected lysate(55.43 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between PRKCD and FYN. HeLa cells were stained with anti-PRKCD rabbit purified polyclonal 1:1200 and anti-FYN mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue). -
Gene Info — FYN
Entrez GeneID
2534GeneBank Accession#
BC032496Protein Accession#
AAH32496Gene Name
FYN
Gene Alias
MGC45350, SLK, SYN
Gene Description
FYN oncogene related to SRC, FGR, YES
Omim ID
137025Gene Ontology
HyperlinkGene Summary
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq
Other Designations
OKT3-induced calcium influx regulator|OTTHUMP00000017914|OTTHUMP00000017915|OTTHUMP00000017917|c-syn protooncogene|protein-tyrosine kinase fyn|proto-oncogene tyrosine-protein kinase fyn|src-like kinase|src/yes-related novel|tyrosine kinase p59fyn(T)
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Interactome
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Pathway
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Disease
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Publication Reference
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Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo.
Chen JH, Huang WC, Bamodu OA, Chang PM, Chao TY, Huang TH.
BMC Cancer 2019 Jun; 19(1):634.
Application：WB-Ce, WB-Tr, Human, Cancer-associated fibroblasts, MCF-7, MDA-MB-231 cells.
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Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo.
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