Western blot analysis of FTL over-expressed 293 cell line, cotransfected with FTL Validated Chimera RNAi ( Cat # H00002512-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with FTL monoclonal antibody (M01), clone 1C2 (Cat # H00002512-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq
L apoferritin,ferritin L subunit,ferritin L-chain,ferritin light chain,ferritin light polypeptide-like 3