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Last updated: 2017/10/15

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FMO3 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00002328-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-FMO3 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 60.1
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-FMO3 antibody (H00002328-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00002328-T01
    FMO3 transfected lysate.
    Western Blot
    QC Testing of H00002328-T01
    Lane 1: FMO3 transfected lysate ( 60.1 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 2328
  • Gene Name:
  • FMO3
  • Gene Alias:
  • FMOII,MGC34400,TMAU,dJ127D3.1
  • Gene Description:
  • flavin containing monooxygenase 3
  • Gene Summary:
  • Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide
  • Other Designations:
  • Flavin-containing monooxygenase-3,OTTHUMP00000033540
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