FMO3 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-FMO3 full-length
Host
Human
Theoretical MW (kDa)
60.1
Interspecies Antigen Sequence
Mouse (79); Rat (81)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-FMO3 antibody (H00002328-B01) by Western Blots.
SDS-PAGE Gel
FMO3 transfected lysate.
Western Blot
Lane 1: FMO3 transfected lysate ( 60.1 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — FMO3
Entrez GeneID
2328GeneBank Accession#
BC032016.1Protein Accession#
AAH32016.1Gene Name
FMO3
Gene Alias
FMOII, MGC34400, TMAU, dJ127D3.1
Gene Description
flavin containing monooxygenase 3
Gene Ontology
HyperlinkGene Summary
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide
Other Designations
Flavin-containing monooxygenase-3|OTTHUMP00000033540
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