FOXM1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human FOXM1 full-length ORF (ADZ15712.1, 1 a.a. - 748 a.a.) recombinant protein with GST tag at N-terminal.
Sequence
MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQAEASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALCEQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKVEEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKQQKRPNPELRRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMSSELARHSKRVRIAPKVLLAEEGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEMPHLARPIKVESPPLEEWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVSEMLVIQHRERRERSRSRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPASQLSYSQEVGGPFKTPIKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTPQGASDPLPDPLGLMDLSTTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
108.7
Interspecies Antigen Sequence
Mouse (78); Rat (79)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — FOXM1
Entrez GeneID
2305GeneBank Accession#
JF432495.1Protein Accession#
ADZ15712.1Gene Name
FOXM1
Gene Alias
FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT
Gene Description
forkhead box M1
Omim ID
602341Gene Ontology
HyperlinkGene Summary
drosophila
Other Designations
Forkhead, drosophila, homolog-like 16|M-phase phosphoprotein 2|forkhead-like 16
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Interactome
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Disease
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Publication Reference
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Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression.
Kun Wang, Xiaoyong Dai, Albert Yu, Chunyan Feng, Kewei Liu, Laiqiang Huang.
Journal of Experimental & Clinical Cancer Research 2022 Sep; 41(1):289.
Application：Screening, Peptides.
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YAP1 induces hyperglycemic stress-mediated cardiac hypertrophy and fibrosis in an AKT-FOXM1 dependent signaling pathway.
Arunima Mondal, Shreya Das, Jayeeta Samanta, Santanu Chakraborty, Arunima Sengupta.
Archives of Biochemistry and Biophysics 2022 Jun; 722:109198.
Application：Cell Culture, Rat, H9c2 cells.
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Honokiol is a FOXM1 antagonist.
Halasi M, Hitchinson B, Shah BN, Varaljai R, Khan I, Benevolenskaya EV, Gaponenko V, Arbiser JL, Gartel AL.
Cell Death & Disease 2018 Jan; 9(2):84.
Application：Func, WB, Human, Compounds, U2OS cells.
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Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression.
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