FKBP3 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human FKBP3 peptide using ARM Technology.
Immunogen
A synthetic peptide of human FKBP3 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human FKBP3 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — FKBP3
Entrez GeneID
2287GeneBank Accession#
FKBP3Gene Name
FKBP3
Gene Alias
FKBP-25, PPIase
Gene Description
FK506 binding protein 3, 25kDa
Omim ID
186947Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq
Other Designations
FK506 binding protein 3 (25kD)|FK506-binding protein 25, T-cell|FK506-binding protein 3 (25kD)|peptidyl-prolyl cis-trans isomerase|rapamycin binding protein|rapamycin-selective 25 kDa immunophilin|rotamase
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Interactome
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Disease
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