FGG monoclonal antibody (M01), clone 1F2
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant FGG.
Immunogen
FGG (AAH07044, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RDNCCILDERFGSYCPTTCGIADFLSTYQTKVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIMKYEASILTHD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (73); Rat (71)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
FGG monoclonal antibody (M01), clone 1F2 Western Blot analysis of FGG expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to FGG on formalin-fixed paraffin-embedded human hepatocellular carcinoma tissue. [antibody concentration 1 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged FGG is approximately 0.3ng/ml as a capture antibody.ELISA
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between ICAM1 and FGG. HeLa cells were stained with anti-ICAM1 rabbit purified polyclonal 1:1200 and anti-FGG mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue). -
Gene Info — FGG
Entrez GeneID
2266GeneBank Accession#
BC007044Protein Accession#
AAH07044Gene Name
FGG
Gene Alias
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Gene Description
fibrinogen gamma chain
Omim ID
134850Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
fibrinogen, gamma chain|fibrinogen, gamma polypeptide
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Interactome
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Pathway
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Disease
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Publication Reference
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Visualization of Neutrophil Extracellular Traps and Fibrin Meshwork in Human Fibrinopurulent Inflammatory Lesions: I. Light Microscopic Study.
Shiogama K,Onouchi T, Mizutani Y,Sakurai K,Inada KI,Tsutsumi Y.
Acta Histochemica et Cytochemica 2016 Aug; 49(4):109.
Application:IHC-P, IEM, Human, Lung tissue of legionnaire's pneumonia.
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Visualization of Neutrophil Extracellular Traps and Fibrin Meshwork in Human Fibrinopurulent Inflammatory Lesions: II. Ultrastructural Study.
Onouchi T,Shiogama K,Matsui T,Mizutani Y,Sakurai K,Inada KI,Tsutsumi Y.
Acta Histochemica et Cytochemica 2016 Aug; 49(4):117.
Application:IHC-P, Human, Human lungs.
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Identification of Novel Diagnostic Biomarkers for Asthma and Chronic Obstructive Pulmonary Disease.
Verrills NM, Irwin JA, He XY, Wood LG, Powell H, Simpson JL, McDonald VM, Sim A, Gibson PG.
American Journal of Respiratory and Critical Care Medicine 2011 Jun; 183(12):1633.
Application:WB, Human, Serum.
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Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics.
Horlock C, Shakib F, Mahdavi J, Jones NS, Sewell HF, Ghaemmaghami AM.
Genome Biology 2007 Mar; 8(3):R30.
Application:ELISA, Human, Human dendritic cells.
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Visualization of Neutrophil Extracellular Traps and Fibrin Meshwork in Human Fibrinopurulent Inflammatory Lesions: I. Light Microscopic Study.
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