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FGFR3 purified MaxPab mouse polyclonal antibody (B01P)MaxPab

  • Catalog # : H00002261-B01P
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  • Specification
  • Product Description:
  • Mouse polyclonal antibody raised against a full-length human FGFR3 protein.
  • Immunogen:
  • FGFR3 (AAI66684.1, 1 a.a. ~ 806 a.a) full-length human protein.
  • Sequence:
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Antibody reactive against mammalian transfected lysate.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Application Image
  • Western Blot (Transfected lysate)
  • Gene Information
  • Entrez GeneID:
  • 2261
  • Gene Name:
  • FGFR3
  • Gene Alias:
  • Gene Description:
  • fibroblast growth factor receptor 3
  • Gene Summary:
  • This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000149959,achondroplasia, thanatophoric dwarfism,hydroxyaryl-protein kinase,tyrosine kinase JTK4
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