FDPS 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
FDPS transfected lysate.
Western Blot
Lane 1: FDPS transfected lysate ( 46.2 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-FDPS full-length
Host
Human
Theoretical MW (kDa)
46.2
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-FDPS antibody (H00002224-B01) by Western Blots.
SDS-PAGE Gel
FDPS transfected lysate.
Western Blot
Lane 1: FDPS transfected lysate ( 46.2 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — FDPS
Entrez GeneID
2224GeneBank Accession#
NM_002004.2Protein Accession#
NP_001995.1Gene Name
FDPS
Gene Alias
FPPS, FPS
Gene Description
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Omim ID
134629Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene
Other Designations
FPP synthetase|OTTHUMP00000015807|OTTHUMP00000015808|farnesyl diphosphate synthase
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Interactome
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Pathway
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Disease
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