FCGRT (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human FCGRT partial ORF ( AAH08734, 51 a.a. - 160 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
GWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAI
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (72); Rat (71)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — FCGRT
Entrez GeneID
2217GeneBank Accession#
BC008734Protein Accession#
AAH08734Gene Name
FCGRT
Gene Alias
FCRN, alpha-chain
Gene Description
Fc fragment of IgG, receptor, transporter, alpha
Omim ID
601437Gene Ontology
HyperlinkGene Summary
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
FcRn alpha chain|IgG Gc receptor|neonatal Fc-receptor
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Interactome
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Disease
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Publication Reference
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Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: evidence for an involvement of the neonatal Fc receptor.
Deissler HL, Lang GK, Lang GE.
Experimental Eye Research 2016 Feb; 143:49.
Application：WB, Bovine, Endothelial cells.
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Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: evidence for an involvement of the neonatal Fc receptor.
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