Immunoprecipitation of FAP transfected lysate using anti-FAP MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with FAP purified MaxPab mouse polyclonal antibody (B01P) (H00002191-B01P).
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [provided by RefSeq