ACSL4 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human ACSL4 full-length ORF ( NP_004449.1, 1 a.a. - 670 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
100.8
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ACSL4
Entrez GeneID
2182GeneBank Accession#
NM_004458.1Protein Accession#
NP_004449.1Gene Name
ACSL4
Gene Alias
ACS4, FACL4, LACS4, MRX63, MRX68
Gene Description
acyl-CoA synthetase long-chain family member 4
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000023846|acyl-CoA synthetase 4|fatty-acid-Coenzyme A ligase, long-chain 4|lignoceroyl-CoA synthase|long-chain fatty-acid-Coenzyme A ligase 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer.
Shengjie Feng, Zejun Rao, Jiakun Zhang, Xiaowei She, Yaqi Chen, Kairui Wan, Haijie Li, Chongchong Zhao, Yongdong Feng, Guihua Wang, Junbo Hu, Xuelai Luo.
Advanced Science (Weinheim, Baden-Württemberg, Germany) 2023 Dec; 10(36):e2303484.
Application:Pull-Down, N/A, Recombinant proteins.
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A Novel TIP30 Protein Complex Regulates EGF Receptor Signaling and Endocytic Degradation.
Zhang C, Li A, Zhang X, Xiao H.
The Journal of Biological Chemistry 2011 Mar; 286(11):9373.
Application:PI, WB-Re, Recombinant protein.
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Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer.
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