F5 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human F5 partial ORF ( NP_000121, 29 a.a. - 128 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
AQLRQFYVAAQGISWSYRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASY
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Interspecies Antigen Sequence
Mouse (84); Rat (90)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — F5
Entrez GeneID
2153GeneBank Accession#
NM_000130Protein Accession#
NP_000121Gene Name
F5
Gene Alias
FVL, PCCF
Gene Description
coagulation factor V (proaccelerin, labile factor)
Gene Ontology
HyperlinkGene Summary
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq
Other Designations
OTTHUMP00000032547|activated protein c cofactor|coagulation factor V|coagulation factor V jinjiang A2 domain|factor V Leiden|labile factor
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Interactome
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Pathway
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Disease
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