ESR2 monoclonal antibody (M01), clone 3F3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ESR2.
Immunogen
ESR2 (NP_001428, 22 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNR
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (84)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ESR2 is approximately 0.3ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to ESR2 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — ESR2
Entrez GeneID
2100GeneBank Accession#
NM_001437Protein Accession#
NP_001428Gene Name
ESR2
Gene Alias
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Gene Description
estrogen receptor 2 (ER beta)
Omim ID
601663Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq
Other Designations
estrogen receptor beta|estrogen receptor beta 4
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Interactome
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Disease
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Publication Reference
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Neonatal exposure to 17β-estradiol down-regulates the expression of synaptogenesis related genes in selected brain regions of adult female rats.
Radhika NS, Govindaraj V, Sarangi SK, Rao AJ.
Life Sciences 2015 Nov; 141:1.
Application:WB, Rat, Brain.
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Neonatal exposure to 17β-estradiol down-regulates the expression of synaptogenesis related genes in selected brain regions of adult female rats.
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