ERCC6 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human ERCC6 partial ORF ( NP_000115, 1394 a.a. - 1493 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
RARNHLILPERLESESGHLQEASALLPTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQSCVFRELLRNLCTFHRTSGGEGIWKLKPEYC
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Interspecies Antigen Sequence
Mouse (83); Rat (76)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ERCC6
Entrez GeneID
2074GeneBank Accession#
NM_000124Protein Accession#
NP_000115Gene Name
ERCC6
Gene Alias
ARMD5, CKN2, COFS, COFS1, CSB, RAD26
Gene Description
excision repair cross-complementing rodent repair deficiency, complementation group 6
Gene Ontology
HyperlinkGene Summary
This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B. [provided by RefSeq
Other Designations
Cockayne syndrome group B protein|OTTHUMP00000019581|Rad26 homolog
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Interactome
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Pathway
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Disease
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