ERCC2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ERCC2 full-length
Host
Human
Theoretical MW (kDa)
83.71
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ERCC2 antibody (H00002068-B01) by Western Blots.
Western Blot
Lane 1: ERCC2 transfected lysate ( 86.9 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
ERCC2 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ERCC2
Entrez GeneID
2068GeneBank Accession#
NM_000400Protein Accession#
NP_000391Gene Name
ERCC2
Gene Alias
COFS2, EM9, MGC102762, MGC126218, MGC126219, TTD, XPD
Gene Description
excision repair cross-complementing rodent repair deficiency, complementation group 2
Gene Ontology
HyperlinkGene Summary
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
excision repair cross-complementing rodent repair deficiency, complementation group 2 protein|xeroderma pigmentosum complementary group D
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Interactome
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Pathway
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Disease
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