ERCC2 monoclonal antibody (M09), clone 2C9
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ERCC2.
Immunogen
ERCC2 (NP_000391, 631 a.a. ~ 730 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHR
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to ERCC2 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — ERCC2
Entrez GeneID
2068GeneBank Accession#
NM_000400Protein Accession#
NP_000391Gene Name
ERCC2
Gene Alias
COFS2, EM9, MGC102762, MGC126218, MGC126219, TTD, XPD
Gene Description
excision repair cross-complementing rodent repair deficiency, complementation group 2
Gene Ontology
HyperlinkGene Summary
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
excision repair cross-complementing rodent repair deficiency, complementation group 2 protein|xeroderma pigmentosum complementary group D
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Interactome
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Pathway
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Disease
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