ENDOG (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human ENDOG full-length ORF ( AAH04922.1, 50 a.a. - 297 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
ELPPVPGGPRGPGELAKYGLPGLAQLKSRESYVLCYDPRTRGALWVVEQLRPERLRGDGDRRECDFREDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNNLEKYSRSLTRSYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGGQIELRTYVMPNAPVDEAIPLERFLVPIESIERASGLLFVPNILARAGSLKAITAGSK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
53.02
Interspecies Antigen Sequence
Mouse (93); Rat (92)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ENDOG
Entrez GeneID
2021GeneBank Accession#
BC004922Protein Accession#
AAH04922.1Gene Name
ENDOG
Gene Alias
FLJ27463
Gene Description
endonuclease G
Omim ID
600440Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq
Other Designations
OTTHUMP00000022301
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Interactome
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Pathway
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Publication Reference
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Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4+ T lymphocytes and prevents the progression of apoptosis.
Zhdanov DD, Gladilina YA, Pokrovsky VS, Grishin DV, Grachev VA, Orlova VS, Pokrovskaya MV, Alexandrova SS, Plyasova AA, Sokolov NN.
Biochimie 2018 Dec; 157:158.
Application:Func, Human, Human lymphocytes.
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[Apoptotic endonuclease EndoG regulates alternative splicing of human telomerase catalytic subunit hTERT].
Zhdanov DD, Vasina DA, Orlova EV, Orlova VS, Pokrovskaya MV, Aleksandrova SS, Sokolov NN.
Biomedit︠s︡inskai︠a︡ Khimii︠a︡ 2016 Jul; 62(5):544.
Application:Func, Human, Caco-2 cells.
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Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4+ T lymphocytes and prevents the progression of apoptosis.
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