CTTN 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
CTTN transfected lysate.
Western Blot
Lane 1: CTTN transfected lysate ( 56.54 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CTTN full-length
Host
Human
Theoretical MW (kDa)
56.54
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CTTN antibody (H00002017-B01) by Western Blots.
SDS-PAGE Gel
CTTN transfected lysate.
Western Blot
Lane 1: CTTN transfected lysate ( 56.54 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CTTN
Entrez GeneID
2017GeneBank Accession#
NM_138565.1Protein Accession#
NP_612632.1Gene Name
CTTN
Gene Alias
EMS1, FLJ34459
Gene Description
cortactin
Omim ID
164765Gene Ontology
HyperlinkGene Summary
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
1110020L01Rik|ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)|oncogene EMS1
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Interactome
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Pathway
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Disease
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