EDNRB DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human EDNRB DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — EDNRB
Entrez GeneID
1910GeneBank Accession#
BC014472.1Protein Accession#
AAH14472.1Gene Name
EDNRB
Gene Alias
ABCDS, ETB, ETBR, ETRB, HSCR, HSCR2
Gene Description
endothelin receptor type B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq
Other Designations
OTTHUMP00000178736|endothelin receptor non-selective type
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Interactome
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Pathway
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Disease
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