EDNRB (Human) Recombinant Protein (Q02)
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More Files
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Specification
Product Description
Human EDNRB partial ORF (AAH14472.1, 27 a.a. - 101 a.a.) recombinant protein with GST tag at N-terminal.
Sequence
EERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
33.88
Interspecies Antigen Sequence
Mouse (67); Rat (68)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — EDNRB
Entrez GeneID
1910GeneBank Accession#
BC014472.1Protein Accession#
AAH14472.1Gene Name
EDNRB
Gene Alias
ABCDS, ETB, ETBR, ETRB, HSCR, HSCR2
Gene Description
endothelin receptor type B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq
Other Designations
OTTHUMP00000178736|endothelin receptor non-selective type
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Interactome
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Pathway
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Disease
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