EDNRB monoclonal antibody (M01), clone 5H2
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant EDNRB.
Immunogen
EDNRB (AAH14472.1, 27 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (67); Rat (68)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (33.88 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged EDNRB is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — EDNRB
Entrez GeneID
1910GeneBank Accession#
BC014472.1Protein Accession#
AAH14472.1Gene Name
EDNRB
Gene Alias
ABCDS, ETB, ETBR, ETRB, HSCR, HSCR2
Gene Description
endothelin receptor type B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq
Other Designations
OTTHUMP00000178736|endothelin receptor non-selective type
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Interactome
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Pathway
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Disease
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