EDN3 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-EDN3 full-length
Host
Human
Theoretical MW (kDa)
25.5
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-EDN3 antibody (H00001908-D01P) by Western Blots.
SDS-PAGE Gel
EDN3 transfected lysate.
Western Blot
Lane 1: EDN3 transfected lysate ( 25.50 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — EDN3
Entrez GeneID
1908GeneBank Accession#
NM_000114.2Protein Accession#
NP_000105.1Gene Name
EDN3
Gene Alias
ET3, MGC15067, MGC61498
Gene Description
endothelin 3
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq
Other Designations
OTTHUMP00000031420|truncated endothelin 3
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Interactome
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Disease
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