E2F6 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-E2F6 full-length
Host
Human
Theoretical MW (kDa)
31.8
Interspecies Antigen Sequence
Mouse (87); Rat (88)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-E2F6 antibody (H00001876-B01) by Western Blots.
SDS-PAGE Gel
E2F6 transfected lysate
Western Blot
Lane 1: E2F6 transfected lysate ( 31.8 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — E2F6
Entrez GeneID
1876GeneBank Accession#
NM_198256Protein Accession#
NP_937987Gene Name
E2F6
Gene Alias
E2F-6, MGC111545
Gene Description
E2F transcription factor 6
Omim ID
602944Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. [provided by RefSeq
Other Designations
E2F transcription factor 6, isoform 1
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Interactome
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Disease
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